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Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells

โœ Scribed by J.C.G. Jeynes; M.J. Bailey; H. Coley; K.J. Kirkby; C. Jeynes

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
456 KB
Volume
268
Category
Article
ISSN
0168-583X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Microbeam PIXE was used to analyse platinum in single ovarian cancer cells. Carboplatin sensitive and resistant cells were grown as a monolayer on polypropylene and treated with either carboplatin or cisplatin. Pt from the carboplatin could not be detected. The Pt from cisplatin in the cells could be detected, and significantly more Zn was found in the resistant cells compared to the sensitive cells. The sensitive cells probably accumulated more cisplatin than the resistant ones.

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