Microarrays in vaccine process development: The effect of oxygen limitation on gene expression during batch cultivation of Bordetella pertussis

Evaluation of a critical process paramet

Evaluation of a critical process parameter: Oxygen limitation during cultivation has a fully reversible effect on gene expression of Bordetella pertussis

✍ Mathieu Streefland; Bas van de Waterbeemd; Joeri Kint; Leo A. van der Pol; E. Co 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 310 KB

## Abstract Modern (bio)pharmaceutical process development requires thorough investigation of all process parameters that are critical to product quality. The impact of a disturbance of such a parameter during processing needs to be known so that a rational decision can be made about the release of