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Michael Addition−Elimination Reactions of Chiral Enolates with Ethyl 3-Halopropenoates

✍ Scribed by Esteban, Jorge; Costa, Anna M.; Gómez, Àlex; Vilarrasa, Jaume


Book ID
120403203
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
120 KB
Volume
10
Category
Article
ISSN
1523-7060

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Utilizing the I\_-valine-based chiral lithioenamine (5) of ethyl acetoacetate (l), enantioface differentiating Michael reaction with alkylidenemalonates (2) gave, after decarboxylation, B-substituted g-keto esters (3) in a fair to good enantiomeric excess. Kinetic diastereoenrichment of the initial