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Michael Addition of Indoles to Electron Deficient Olefins in Water Catalyzed by Potassium Bisulfate.

โœ Scribed by R. Senthil Kumar; Paramasivan T. Perumal


Publisher
John Wiley and Sons
Year
2007
Weight
23 KB
Volume
38
Category
Article
ISSN
0931-7597

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The Ultra High Pressure Conjugate Addition of Indoles to Electron-Deficient Olefins. -Indole and methylindole are added to ฮฑ,ฮฒ-unsaturated ketones in the presence of catalytic amounts of Yb(OTf) 3 to afford 3-alkylated indoles. The more reactive and less sterically hindered electrophiles give good t