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Michael addition of dimedone with α,β-unsaturated ketones: Synthesis of quinoline and chromene derivatives

✍ Scribed by Dhananjay B. Kendre; Raghunath B. Toche; Madhukar N. Jachak

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
421 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of quinoline and chromene derivatives has been synthesized by Michael addition of dimedone 1 with 2‐aroyl‐3‐arylacrylonitrile 2 and study of absorption and fluorescence maxima of quinolines.

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Organocatalytic Michael Addition of Naphthoquinone with α,β-Unsaturated Ketones: Primary Amine Catalyzed Asymmetric Synthesis of Lapachol Analogues
✍ Guangcun Zhang; Yifeng Wang; Wei Zhang; Xiangsheng Xu; Aiguo Zhong; Danqian Xu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB

## Abstract A highly efficient organocatalytic synthesis of lapachol analogues from the Michael addition of naphthoquinone to various α,β‐unsaturated ketones catalyzed by primary amines is presented. Good to high yields (up to 93 %) and high to excellent enantioselectivities (up to 98 % __ee__) wer