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Michael addition of 4-0-ethyluracil. A method for specific N1-alkylation of hydroxypyrimidines.

✍ Scribed by A.J.H. Nollet; U.K. Pandit

Publisher: Elsevier Science
Year: 1969
Tongue: French
Weight: 92 KB
Volume: 10
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)88761-x

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✦ Synopsis

Current interest in the synthesis of nuoleotide-components and their analoguea has led to the quest for new methods of specific N, -alkylation of uracil and related pyrimidine derivatives, in this laboratory. The N,-cyanoethylation of uracil has been previoualy reported 495 , but the conditions employed for the reaction were highly specific and subtle variations diverted the course of the reaction to N,,N3-dialkylation.

In order to develop a procedure which would unambiguously give the mono N,-alkylated product and moreover, be capable of general application , we have examined the reaction of

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