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Micelles from Amphiphilic Block Copolyphosphates for Drug Delivery

✍ Scribed by Xiang Zhai; Wei Huang; Jinyao Liu; Yan Pang; Xinyuan Zhu; Yongfeng Zhou; Deyue Yan

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
499 KB
Volume
11
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Amphiphilic block copolyphosphates (PEP__‐b‐PIPPs) are synthesized by two‐step ROP of cyclic phosphate monomers with different pedant groups. They can spontaneously self‐assemble into approximately spherical micelles ranging in size between 89 and 198 nm in water. A typical hydrophobic anti‐cancer drug DOX is encapsulated into the micelles. The release rate of DOX slows down with increasing hydrophobic block length of PIPP. DOX‐loaded micelles are investigated for the proliferation inhibition of Hela cells and the DOX dose required for 50% cellular growth inhibition is found to be 0.8 ¡g mL^βˆ’1^. It is demonstrated that PEP‐b‐__PIPP micelles can be used as a safe and promising drug delivery system.magnified image

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