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Mice carrying a conditional Serca2flox allele for the generation of Ca2+ handling-deficient mouse models

✍ Scribed by Kristin B. Andersson; Alexandra V. Finsen; Cecilie Sjåland; Lisbeth H. Winer; Ivar Sjaastad; Annlaug Ødegaard; William E. Louch; Yibin Wang; Ju Chen; Kenneth R. Chien; Ole M. Sejersted; Geir Christensen

Book ID
113525820
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
778 KB
Volume
46
Category
Article
ISSN
0143-4160

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Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
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## Abstract To study biologically relevant functions of the Janus kinase 2 (Jak2) in multiple cytokine and hormone receptor signal transduction pathways, we generated a conditional knockout (floxed) allele of this gene by placing __lox__P sites around the first coding exon of __Jak2__. Homozygous f