Mianserin suppositories in the treatment of post-operative delirium

✍ Scribed by Jun Nakamura; Naohisa Uchimura; Shigeto Yamada; Hisao Maeda; Shigenobu Ishida; Satoshi Tsuchiya; Takashi Hirano; Hiroki Ishii; Katsuhiko Takayama; Tsuyoshi Kotorii

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 98 KB
• Volume: 12
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199711/12)12:6<595::aid-hup929>3.0.co;2-9

✦ Synopsis

Mianserin suppositories (10±90 mg) were administered at bedtime to 16 patients with post-operative delirium (mean age 69 . 5 years). By the Delirium Rating Scale (DRS: Trzepacz et al., 1988), the average score decreased from 21 . 2 prior to administration to 14 . 5 on the ®rst day of treatment and to 7 . 1 on the seventh day. Improvement was observed in all cases (marked in 85 per cent and slight in 15 per cent). The plasma concentration of mianserin was 65 ng/ml on day 1, 93 ng/ml on day 3 and 65 ng/ml on day 5, having reached therapeutic levels within 24 h of beginning treatment. Decreases in the free-3-methoxy-4-hydroxyphenyl(ethylene)glycol (MHPG) concentrations in plasma were observed after drug administration, but free-homovanillic acid (HVA) concentrations in plasma showed no signi®cant change with the drug treatment. We consider mianserin suppositories to be an eective treatment for post-operative delirium.