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MHC-II crosslinking promotes lipid-raft dependent MHC-II clustering, endocytosis, and degradation in dendritic cells

✍ Scribed by Paul Roche; Kazuyuki Furuta; Satoshi Ishido


Book ID
113805760
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
54 KB
Volume
51
Category
Article
ISSN
0161-5890

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In the normal central nervous system (CNS) expression of MHC class II is minimal, but has been found to be highly up-regulated on microglia cells in experimental autoimmune encephalitis (EAE). Here we used the EAE model to examine the regulation of expression of the class II transactivator (CIITA),