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MHC II and the Endocytic Pathway: Regulation by Invariant Chain

โœ Scribed by O. J. B. Landsverk; O. Bakke; T. F. Gregers


Book ID
110861818
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
230 KB
Volume
70
Category
Article
ISSN
0300-9475

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MHC class II-associated invariant chain
โœ Georg Malcherek; Christoph Wirblich; Nicholas Willcox; Hans-Georg Rammensee; Joh ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 198 KB

Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e