MHC-I antigen expression determines sensitivity of hematopoetic progenitor cells as targets for NK cells

β2 -Microglobulin-deficient NK cells sho

β2 -Microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains

✍ Petter Höglund; Rickard Glas; Carine Ménard; Anna Kåse; Maria H. Johansson; Lars 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB

Mice lacking beta2-microglobulin (beta2m- mice) express greatly reduced levels of MHC class I molecules, and cells from beta2m- mice are therefore highly sensitive to NK cells. However, NK cells from beta2m- mice fail to kill beta2m- normal cells, showing that they are self tolerant. In a first atte