Mouse Sal sarcoma cells are lethal in the autologous A/J (K") host. In order t o improve the immune response t o the Sal tumor, Sal cells have been transfected with syngeneic MHC-class-ll or allogeneic MHC-class4 genes. MHC-class-ll transfectants are uniformly rejected by the autologous host and imm
β¦ LIBER β¦
MHC Class II-Transfected Tumor Cells Induce Long-Term Tumor-Specific Immunity in Autologous Mice
β Scribed by Sivasubramanian Baskar; Viola Azarenko; Elizabeth Garcia Marshall; Eric Hughes; Suzanne Ostrand-Rosenberg
- Book ID
- 112238947
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 420 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0008-8749
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## Abstract Sublethally irradiated BALB/c mice innoculated with Moloney sarcoma virus (MSVβM) develop progressively growing tumors and die within 30 days of virus innoculation. These animals can be protected from tumor progression (and death) by innoculation of small numbers of MSVβimmune T lymphoc