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MHC class II-restricted tumor antigens and CD4+ T cells play a role in hematological malignancies as well as solid tumors

✍ Scribed by Graham Pawelec; Ludmila Müller; Wolfgang Wagner

Book ID: 117786978
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 37 KB
Volume: 22
Category: Article
ISSN: 1471-4906
DOI: 10.1016/s1471-4906(01)01987-1

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## Abstract Malignant gliomas (MGs), lethal human central nervous system (CNS) neoplasms, contain tumor infiltrating lymphocytes (TIL). Although MHC class II molecules are frequently detected on MG cells, suggesting that they may be capable of antigen (Ag) presentation to CD4^+^ T cells, deficienci