MHC class I expression protects target cells from lysis by Ly49-deficient fetal NK cells
✍ Scribed by Jennifer A. Toomey; Sunil Shrestha; Sarah A. de la Rue; Frances Gays; John H. Robinson; Zosia M. A. Chrzanowska-Lightowlers; Colin G. Brooks
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 176 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Murine natural killer (NK) cells are inhibited by target cell MHC class I molecules __via__ Ly49 receptors. However, Ly49 receptors can be made inaccessible to target cell MHC class I by a __cis__ interaction with its MHC class I ligand within the NK cell membrane. It has recently been
Mice lacking beta2-microglobulin (beta2m- mice) express greatly reduced levels of MHC class I molecules, and cells from beta2m- mice are therefore highly sensitive to NK cells. However, NK cells from beta2m- mice fail to kill beta2m- normal cells, showing that they are self tolerant. In a first atte