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MHC antigen expression in normal developing human kidney and Wilms' tumour

✍ Scribed by G.M Borthwick; C.H Holmes; S.J Davis; G.M Stirrat


Book ID
119090834
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
54 KB
Volume
15
Category
Article
ISSN
0165-0378

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W T l , the Wilms' tumour suppressor gene located at chromosome llp13, plays an important role in the development of the kidney. It is mutated in 10 per cent of Wilms' tumours (WTs) and their putative precursors called nephrogenic rests (NRs). A sensitive immunohistochemical technique was establishe