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MGMTpromoter methylation, loss of expression and prognosis in 855 colorectal cancers

✍ Scribed by Kaori Shima; Teppei Morikawa; Yoshifumi Baba; Katsuhiko Nosho; Maiko Suzuki; Mai Yamauchi; Marika Hayashi; Edward Giovannucci; Charles S. Fuchs; Shuji Ogino

Book ID
106383213
Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
271 KB
Volume
22
Category
Article
ISSN
0957-5243

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Prognostic significance of CDKN2A (p16)
Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review
✍ Kaori Shima; Katsuhiko Nosho; Yoshifumi Baba; Mami Cantor; Jeffrey A. Meyerhardt πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 405 KB

## Abstract A cyclin‐dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A