MGMT promoter methylation and immunoexpression in aggressive pituitary adenomas and carcinomas
โ Scribed by Fateme Salehi; Bernd W. Scheithauer; Johann M. Kros; Queenie Lau; Michael Fealey; Dana Erickson; Kalman Kovacs; Eva Horvath; Ricardo V. Lloyd
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 201 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Uveal melanoma is associated with a high mortality rate once metastases occur, with over >90% of metastatic patients dying within less than 1 year from metastases to the liver. The intraarterial hepatic (iah) administration of the alkylating agent fotemustine holds some promise with res
The enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In established cancer cell lines, MGMT expression appears t