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mGluR7-like receptor and GABAB receptor activation enhance neurotoxic effects of N-methyl-d-aspartate in cultured mouse striatal GABAergic neurones

✍ Scribed by Mireille Lafon-Cazal; Gaëlle Viennois; Rainer Kuhn; Barbara Malitschek; Jean-Philippe Pin; Ryuichi Shigemoto; Joël Bockaert


Book ID
117188375
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
828 KB
Volume
38
Category
Article
ISSN
0028-3908

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Cultures of chicken day 8 embryo retinal cells, essentially free of contaminating non-neuronal elements, were used to examine the neurotoxicity of various excitatory amino acid transmitter receptor agonists. At 7 days in vitro, N-methyl-D-aspartate (NMDA), following 24 hr exposure to 0.1-1.0 mM, des