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mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C

✍ Scribed by Vytenis A Skeberdis; Jian-yu Lan; Thoralf Opitz; Xin Zheng; Michael V.L Bennett; R.Suzanne Zukin


Book ID
117187126
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
390 KB
Volume
40
Category
Article
ISSN
0028-3908

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## Abstract Galantamine, a novel Alzheimer's drug, is known to inhibit acetylcholinesterase activity and potentiate nicotinic acetylcholine receptor (nAChR) in the brain. We previously reported that galantamine potentiates the NMDA‐induced currents in primary cultured rat cortical neurons. We now s