Mg2+-mediated self-assembly of an amphiphilic pyrene derivative with single-stranded DNA

✍ Scribed by Jinchong Xiao; Junbo Li; Cuihong Li; Changshui Huang; Yuliang Li; Shuang Cui; Shu Wang; Huibiao Liu

• Book ID: 104095070
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 532 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.02.024

✦ Synopsis

An amphiphilic ethynyl-pyrene derivative modified with phosphonic acid groups (PyTOH) was synthesized and characterized. Singlestranded DNA (ssDNA), which carries negative charges, was found to induce the self-assembly of PyTOH through electrostatic interactions with Mg 2+ as co-complexation ion in aqueous solution. UV-vis, fluorescence, and circular dichroism (CD) spectra revealed that left-handed helical architecture of PyTOH/Mg 2+ /DNA was formed. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) showed that nanoscale structures could be fabricated by self-assembly.