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Mg-Al 3:1 hydrotalcite catalyst in the synthesis of cyclopropane carboxylic acid derivatives

✍ Scribed by Zoltán Finta; Zoltán Hell; Daniella Balán; Agnieszka Cwik; Sándor Kemény; François Figueras

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
134 KB
Volume
161
Category
Article
ISSN
1381-1169

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✦ Synopsis

The non-activated Mg-Al 3:1 hydrotalcite is a suitable basic catalyst both in the intramolecular cyclization reaction of malonic acid allylic esters into bicyclic cyclopropane carboxylic acid lactones and the intermolecular cyclization reaction of dibromoethane and diethyl malonate into cyclopropane dicarboxylic acid diester. The optimal reaction conditions of the intramolecular cyclization were determined using a 2 4 factorial design. An interesting effect on the diastereoselectivity of the intramolecular cyclization was observed compared with the diastereoselectivity of this cyclization using solid potassium carbonate as base.

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