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Mexiletine pharmacokinetics and debrisoquine hydroxylator status

✍ Scribed by P. Lledo; S.M.L. Abrams; A. Johnston; R.M. Pearson

Book ID
115885778
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
94 KB
Volume
183
Category
Article
ISSN
0014-2999

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πŸ“œ SIMILAR VOLUMES

Influence of debrisoquine hydroxylation
Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine
✍ P. LledΓ³; S. M. L. Abrams; A. Johnston; M. Patel; R. M. Pearson; P. Turner πŸ“‚ Article πŸ“… 1993 πŸ› Springer 🌐 English βš– 521 KB

Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine