Metiamide—An orally active histamine H2-receptor antagonist
✍ Scribed by J. W. Black; W. A. M. Duncan; J. C. Emmett; C. R. Ganellin; T. Hesselbo; M. E. Parsons; J. H. Wyllie
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1994
- Tongue
- English
- Weight
- 505 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1420-908X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The requirements for H -antagonist activity so far identified for most of 2 the known antagonists of histamine are the presence of a heterocyclic ring containing a basic center linked via a methylene chain to a substituted guanidine or thiourea polar Ž . side chain. Metiamide is a potent H antagonis
## Abstract A key role has been established for platelet activation and thrombus formation in the pathogenesis of acute coronary syndromes, and restenosis after percutaneous interventions. Antiplatelet agents that have a wider spectrum of activity than aspirin, and clopidogrel would be expected to
The synthesis of [3H]L-734,217, lb, an orally active fibrinogen receptor antagonist, is described. The conversion of 3-amino crotonate 6 to [3H]L-734,217 was carried out via a two step sequence of catalytic tritiation followed by basic hydrolysis. Deuterium model reactions showed that the reduction