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Methylxanthines Reverse the Adipsic and Aphagic Syndrome Induced by Bilateral 6-Hydroxydopamine Lesions of the Nigrostriatal Pathway in Rats

✍ Scribed by M Casas; G Prat; P Robledo; M Barbanoj; J Kulisevsky; F Jané


Book ID
114101955
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
167 KB
Volume
66
Category
Article
ISSN
0091-3057

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✍ A. J. Stoessl; C. T. Dourish; S. D. Iversen 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 669 KB

Apomorphine-induced yawning was studied in male rats with bilateral 6-hydroxydopamine lesions of the substantia nigra. Apomorphine 10, 20 and 50 lag/kg SC induced dose-dependent yawning in unoperated controls and animals with sham lesions. In the lesioned animals (in which the mean striatal dopamine