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Methylxanthines and breast cancer

โœ Scribed by Thomas E. Rohan; Anthony J. McMichael


Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
499 KB
Volume
41
Category
Article
ISSN
0020-7136

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โœฆ Synopsis


The association between intake of methylxanthines and risk of breast cancer was examined in this population-based casecontrol study conducted in Adelaide, South Australia. The study included 451 cases, and one control was matched to each case for age (to the nearest year). Overall, and within the post-menopausal stratum, there was relatively little variation in the risk of breast cancer in association with total caffeine and total methylxanthine intake. In pre-menopausal women, risk was increased at the higher levels of intake, but the increase in risk was not dose-dependent. There was no evidence for an effect of methylxanthines at high levels of fat intake. Prior epidemiological and experimental studies have not provided strong support for a positive association between intake of methylxanthines and risk of breast cancer. However, the possibility that they are linked through an association between methylxanthines and those histological subcategories of benign breast disease which are strongly associated with risk of breast cancer is discussed.


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