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Methylglyoxal-mediated alteration of gene expression in human endothelial cells

✍ Scribed by Seung Eun Lee; Hana Yang; Seong Il Jeong; Young-Ho Jin; Cheung-Seog Park; Yong Seek Park


Book ID
107689682
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
246 KB
Volume
5
Category
Article
ISSN
1976-0280

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## Abstract The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor‐1 (PAI‐1) in cultured endothelial cells (ECs). Transfection of PAI‐1 promoter‐luciferase reporter deletion constructs identified a 251‐bp fragment (nucleotides