The enantioselective hydrogenation of methyl benzoylformate (MBF) and pyruvaldehyde dimethyl acetal (PA) was investigated under mild experimental conditions on Pt-alumina catalyst modified with MeOCD, MeOCN, MeOQN and MeOQD alkaloid derivatives in acetic acid (AcOH) and in toluene (T). Besides low r
✦ LIBER ✦
Methylethers of cinchona alkaloids in Pt-catalyzed hydrogenation of ethyl pyruvate and ketopantolactone: Effect of stereochemical factors on the enantioselectivity
✍ Scribed by Katalin Balázsik; Imre Bucsi; Szabolcs Cserényi; György Szöllősi; Mihály Bartók
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 849 KB
- Volume
- 280
- Category
- Article
- ISSN
- 1381-1169
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The origin of rate enhancement in the enantioselective heterogeneous catalytic hydrogenation of ethyl pyruvate on Pt modified with the parent cinchonas, as compared to the unmodified Pt, was studied in a solvent mixture toluene/AcOH 9/1. Hydrogenation experiments were carried out in a continuousflow