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Methylethers of cinchona alkaloids in Pt-catalyzed hydrogenation of ethyl pyruvate and ketopantolactone: Effect of stereochemical factors on the enantioselectivity

✍ Scribed by Katalin Balázsik; Imre Bucsi; Szabolcs Cserényi; György Szöllősi; Mihály Bartók


Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
849 KB
Volume
280
Category
Article
ISSN
1381-1169

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The origin of rate enhancement in the enantioselective heterogeneous catalytic hydrogenation of ethyl pyruvate on Pt modified with the parent cinchonas, as compared to the unmodified Pt, was studied in a solvent mixture toluene/AcOH 9/1. Hydrogenation experiments were carried out in a continuousflow