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Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis

✍ Scribed by Elias Zintzaras; Katrin Uhlig; George N. Koukoulis; Afroditi A. Papathanasiou; Ioannis Stefanidis

Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
256 KB
Volume
52
Category
Article
ISSN
1435-232X

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✍ Ou, C Y; Stevenson, R E; Brown, V K; Schwartz, C E; Allen, W P; Khoury, M J; Roz πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 19 KB πŸ‘ 2 views

Persons with a thermolabile form of the enzyme 5,lO methylenetetrahydrofolate reductase (MTHFR) have reduced enzyme activity and increased plasma homocysteine which can be lowered by supplemental folic acid. Thermolability of the enzyme has recently been shown to be caused by a common mutation (677C