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Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice

โœ Scribed by Laura Pickell; Deqiang Li; Katharine Brown; Leonie G. Mikael; Xiao-Ling Wang; Qing Wu; Li Luo; Loydie Jerome-Majewska; Rima Rozen

Book ID
118282271
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
627 KB
Volume
85
Category
Article
ISSN
1542-0752

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Impact of methylenetetrahydrofolate redu
Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice
โœ Deqiang Li; Laura Pickell; Ying Liu; Rima Rozen ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 93 KB ๐Ÿ‘ 2 views

## BACKGROUND: The etiology of neural tube defects (NTDs) is multifactorial, with environmental and genetic determinants. Folate supplementation prevents the majority of NTDs, and a polymorphism in methylenetetrahydrofolate reductase (MTHFR) has become recognized as a genetic risk factor. The mech