Methylenedioxyphenyl substituted compounds from Piper species as inhibitors of liver microsome-mediated aflatoxin B1-DNA binding in vitro
✍ Scribed by Hanumantharao G. Raj; Sangita Gupta; Ashok K. Prasad; Per M. Boll; Jesper Wengel; Gopa Biswas; Sanjay K. Singh; Nawal K. Sharma; Kirpal S. Bisht; Virinder S. Parmar
- Book ID
- 103983005
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 279 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
Several compounds from Piper species bearing methylenedioxyphenyi moieties are reported for the first time to effectively inhibit the rat liver microsome-mediated afiatoxin B~-DNA binding in vitro. From the preliminary results obtained, a structure-activity relationship is proposed.
Attatoxin B 1 (AFB1), a secondary metabolite of Aspergillus flavus has been recognised as a potent hepatocareinogen for several animal species. 1 It is also a suspected human carcinogen? AFB1 exerts its biological effect after conversion to a reactive metabolite, i.e. AFBt-8,9-epoxide by cytochrome P-450 dependent