Methylene blue-mediated photodynamic therapy: A possible alternative treatment for oral lichen planus
✍ Scribed by Farzane Aghahosseini; Fateme Arbabi-Kalati; Leila Ataie Fashtami; Gholamreza Esmaeeli Djavid; Mohsen Fateh; Jalil Momen Beitollahi
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 173 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0196-8092
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
BACKGROUND AND OBJECTIVES
In this study, methylene blue‐mediated photodynamic therapy (MB‐PDT) was used as a possible alternative method for the treatment of oral lichen planus (OLP).
STUDY DESIGN/MATERIALS AND METHODS
Thirteen patients with 26 OLP lesions were enrolled in this study. Patients were instructed to gargle a 5% methylene blue solution in water for 5 minutes. Ten minutes later, irradiation was performed by laser light (λ = 632 nm, light exposure dose = 120 J/cm^2^). Lesions were evaluated pre and post‐operatively and at follow‐up sessions by changes in sign and symptom (pain) scores, and size of lesions.
RESULTS
Improvement in sign scores was achieved in 16 lesions. Four keratotic lesions disappeared completely. There was a statistically significant decrease in sign and symptom scores 1 week after treatment and at follow‐up sessions up to 12 weeks. Average reduction in size of lesions was 44.3%.
CONCLUSION
MB‐PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB‐PDT in control of OLP for a longer period of time. Lasers Surg. Med. © 2005 Wiley‐Liss, Inc.