𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Methylene Blue-Conjugated Hydrogel Nanoparticles and Tumor-Cell Targeted Photodynamic Therapy

✍ Scribed by Hoe Jin Hah; Gwangseong Kim; Yong-Eun Koo Lee; Daniel A. Orringer; Oren Sagher; Martin A. Philbert; Raoul Kopelman

Book ID
102933904
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
744 KB
Volume
11
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Methylene blue‐conjugated polyacrylamide nanoparticles are prepared through a microemulsion polymerization, after conjugation of the dye with a monomer. The nanoparticles have a 50–60 nm diameter in solution. This conjugation method enables a large increase in loading of methylene blue per nanoparticle and also minimizes dye leaching out of the nanoparticle. Furthermore, the dye content can be controlled by variation of the dye amount, enabling a more refined control of the singlet oxygen production ability. The nanoparticles are coated with F3 peptides, which give specific targeting to selected tumor cells, 9L, MDA‐MB‐435, and F98, in vitro. In addition, MTT assays reveal that the nanoparticles have no dark toxicity but excellent PDT efficacy increasing with the nanoparticle dose and irradiation time. magnified image

πŸ“œ SIMILAR VOLUMES

Methylene blue-mediated photodynamic the
Methylene blue-mediated photodynamic therapy induces mitochondria-dependent apoptosis in HeLa Cell
✍ Yan Lu; Ruiqing Jiao; Xiaoping Chen; Jieying Zhong; Jianguo Ji; Pingping Shen πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 306 KB

## Abstract Methylene blue (MB), a widely studied reagent, is investigated in this work for its usage in photodynamic therapy (PDT). PDT has been proved to be highly effective in the treatment of different types of cancers. Previous studies showed MB has both high affinity for mitochondria and high

Factors influencing tumor response to ph
Factors influencing tumor response to photodynamic therapy sensitized by intratumor administration of methylene blue
✍ Timothy M. Baran; Benjamin R. Giesselman; Rui Hu; Merrill A. Biel; Thomas H. Fos πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 283 KB

## Abstract ## Background and Objectives We examined tumor response to methylene blue (MB)‐mediated photodynamic therapy (PDT) in a murine tumor model. The goal was to investigate the effects of drug–light interval (DLI), injection vehicle, and fluence on tumor destruction. Fluorescence and reflec