Methylcobalamin and methylcobalt complexes of vitamin B12 model compounds as substrates in nucleophilic displacement reactions

✍ Scribed by E.A. Stadlbauer; R.J. Holland; F.P. Lamm; G.N. Schrauzer

• Book ID: 104105954
• Publisher: Elsevier Science
• Year: 1974
• Weight: 706 KB
• Volume: 4
• Category: Article
• ISSN: 0006-3061
• DOI: 10.1016/s0006-3061(00)80175-1

✦ Synopsis

Methylcobslamin and methylcobalt derivatives of vitamin 31~ model compounds, in particuhu, the methylcobalt derivative of BFrsubstituted biiethylglyoximatocobalt complexes, react with a variety of strong nucleophiles in a manner typical of nucleophilic displacement reactions, i.e., according to thy equation: YH3 (Co) + Y-4 Y-CHs + (Car)-, where Y-denotes the attacking nucleophiIe and (Co) the parent cobalt chelate-Nucleophiles which react in this fashion include: RS, Cl-, Br-, I-, CN, Pbz-C,Hds PGHdr, Se-. Higher alkylcobalt derivatives also react with strong nucleophiles, but by way of olefin elimination rather than nucleophilic displacement.