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Methylation profiles of theBRCA1promoter in hereditary and sporadic breast cancer among Han Chinese

✍ Scribed by Da Pang, Yashuang Zhao, Weinan Xue, Ming Shan, Yanbo Chen, Youxue Zhang, Guoqiang Zhang, Feng Liu, Dalin Li, Yanmei Yang

Book ID
118821491
Publisher
Springer US
Year
2011
Tongue
English
Weight
373 KB
Volume
29
Category
Article
ISSN
1357-0560

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## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_