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Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer

โœ Scribed by D. Katsaros; W. Cho; R. Singal; S. Fracchioli; I.A. Rigault de la Longrais; R. Arisio; M. Massobrio; M. Smith; W. Zheng; J. Glass; H. Yu

Book ID
113959409
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
409 KB
Volume
94
Category
Article
ISSN
0090-8258

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Alteration of p16 and p15 genes in commo
Alteration of p16 and p15 genes in common epithelial ovarian tumors
โœ Masami Fujita; Takayuki Enomoto; Tomoko Haba; Ryuichi Nakashima; Makoto Sasaki; ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 244 KB ๐Ÿ‘ 2 views

We have examined the roles of 2 putative tumor-suppressor genes, the p16 and p15 inhibitor-of-cyclin-dependentkinase genes, in the most commonly occurring epithelial tumors of the human ovary. Expression of p16 mRNA, examined by RT-PCR, was significantly reduced in 15 of the 48 tumors. Aberrant expr