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Methylation of the RARB Gene Increases Prostate Cancer Risk in Black Americans

✍ Scribed by Tang, Deliang; Kryvenko, Oleksandr N.; Mitrache, Nicoleta; Do, Kieu C.; Jankowski, Michelle; Chitale, Dhananjay A.; Trudeau, Sheri; Rundle, Andrew; Belinsky, Steven A.; Rybicki, Benjamin A.


Book ID
122758868
Publisher
Lippincott Williams and Wilkins
Year
2013
Tongue
English
Weight
380 KB
Volume
190
Category
Article
ISSN
0022-5347

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## Abstract Retinoic acid receptor B2 (__RARB2__) is frequently inactivated in cancer. Methylation in the 5′‐untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that hypo‐ and hypermethylated