## Abstract Insulinโlike growth factor binding proteinโ3 (IGFBPโ3) is postulated to be a mediator of growth suppression signals. Here, we examined the methylation status of __IGFBPโ3__ to correlate to clinicopathological factors in human cancers. The methylation status of __IGFBPโ3__ was determined
Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer
โ Scribed by A. WILEY; D. KATSAROS; S. FRACCHIOLI; H. YU
- Book ID
- 109085560
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 251 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1048-891X
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## Abstract Recent epidemiological studies have shown that high serum levels of insulinโlike growth factorโI (IGFโI) are associated with an increased risk of lung, colon, breast and prostate cancer. Since very few studies have addressed the role of serum levels of IGFโI in the development of pancre
The mitogenic effects of insulin-like growth factors (IGFs) are regulated by a family of insulin-like growth factor binding proteins (IGFBPs). One member of this family, IGFBP-3, mediates the growth-inhibitory and apoptosis-inducing effects of a number of growth factors and hormones such as transfor