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Methylation of the imprinted GNAS1 gene in cell-free plasma DNA: equal steady-state quantities of methylated and unmethylated DNA in plasma

✍ Scribed by William M. Puszyk; Kamaljit Chatha; Selina Elsenheimer; Francesco Crea; Robert W. Old


Book ID
116348111
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
435 KB
Volume
400
Category
Article
ISSN
0009-8981

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## Abstract Abnormal DNA methylation is a feature of most types of cancer, which is reflected in cell‐free circulating DNA in plasma. It is, however, unknown whether surgical removal of the tumor and subsequent therapy induces changes in plasma DNA methylation, which can be used to monitor treatmen