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Methylation of platinum complexes by methylcobalamin

โœ Scribed by Fanchiang, Y. T.; Ridley, W. P.; Wood, J. M.

Book ID
121879099
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
674 KB
Volume
101
Category
Article
ISSN
0002-7863

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โœ Robert T. Taylor; M.Leslie Hanna ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Elsevier Science โš– 711 KB

Incubation of microM levels of K2PtCl6 and methylcobalamin (MeB-12) results in the complete conversion of MeB-12 to aquoB-12. Demethylation is optimal at pH 2.0 and is accelerated by the addition of K2PtCl4. The reaction is stoichiometric between MeB-12 and K2PtCl6 (1:1). Incubation of 40 microM K2P