Methylation of deoxyribonucleic acid in the rat by the mushroom poison gyromitrin
β Scribed by Meier-Bratschi, Annelis; Carden, Brian M.; Luethy, Juerg; Lutz, Werner K.; Schlatter, Christian
- Book ID
- 127227039
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 554 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0021-8561
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Consumption of false morel (Gyromitra esculenta Fr.) has been associated not only with acute poisoning, but also with a carcinogenic risk. The hydrolysis of acetaldehyde-N-methyl-N-formylhydrazone (gyromitrin, the main toxic component of false morel) results in the formation of the methylating agent
Dietary zinc deficiency has been shown to decrease the in vivo incor. poration of thymidine into the nuclear DNA of liver parenchymal cells in the rat. A single injection of 100 pg of zinc was sufficient to rapidly reverse the effect of zinc deficiency on the synthesis of DNA.