In the title compound, C 9 H 12 N 4 , the asymmetric unit contains one half-molecule. The C atom of the bridging methylene group lies on a twofold rotation axis. The dihedral angle between the symmetry-related imidazole rings is 88.1 (2) .
Methylation of bis(1,3-diketo-2-cyclohexyl)methanes
✍ Scribed by Ya. K. Lemba; I. E. Lielbriedis
- Book ID
- 112325112
- Publisher
- Springer US
- Year
- 1975
- Tongue
- English
- Weight
- 266 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0009-3122
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In the title compound, C 15 H 18 Cl 2 S 2 , the molecule has a crystallographic twofold axis. The dihedral angle between the symmetry-related thiophene rings is 85.54 (8) .
The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity