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Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

✍ Scribed by Cha, B; Kim, W; Kim, Y K; Hwang, B N; Park, S Y; Yoon, J W; Park, W S; Cho, J W; Bedford, M T; Jho, E-h

Book ID
109972723
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
689 KB
Volume
30
Category
Article
ISSN
0950-9232

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## Abstract **Background:** Wnt signalling plays a critical role in many developmental processes and tumorigenesis. Wnt/β‐catenin signalling induces the stabilization of cytosolic β‐catenin, which interacts with TCF/LEF‐1 transcription factors, thereby inducing expression of Wnt‐target genes. Recen