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Methylation and silencing of the Thrombospondin-1 promoter in human cancer

✍ Scribed by Li, Qing; Ahuja, Nita; Burger, Peter C; Issa, Jean-Pierre J


Book ID
110062097
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
237 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract The __HSulf‐1__ gene is an important factor that modulates the sulfation status of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix, resulting in disturbance of HSPG‐related signal transduction pathways. Recently, __HSulf‐1__ has been reported to be down‐regulated in se