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Methylation and Gene Silencing of the Ras-Related GTPase Gene in Lung and Breast Cancers

โœ Scribed by Makoto Suzuki; Hisayuki Shigematsu; David S. Shames; Noriaki Sunaga; Takao Takahashi; Narayan Shivapurkar; Toshihiko Iizasa; John D. Minna; Takehiko Fujisawa; Adi F. Gazdar

Book ID
111771747
Publisher
Springer
Year
2006
Tongue
English
Weight
333 KB
Volume
14
Category
Article
ISSN
1068-9265

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Epigenetic silencing of maspin gene expr
Epigenetic silencing of maspin gene expression in human breast cancers
โœ Frederick E. Domann; Judd C. Rice; Mary J.C. Hendrix; Bernard W. Futscher ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 135 KB ๐Ÿ‘ 2 views

Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most