Methylation and demethylation ofInk4locus in cancer development
β Scribed by Da-jun Deng; Qiang Li; Xiu-hong Wang
- Book ID
- 107467035
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2010
- Tongue
- English
- Weight
- 567 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1000-9604
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Metabolites of dimethylarsinic acid (DMA) were studied in rats chronically exposed to DMA in drinking water. The urine was collected by forced urination at the end of 8, 20 and 30 weeks and the feces at the end of 30 weeks. The samples were analyzed for arsenic species by a combined system of ion ch
## Abstract Epigenetic modification of the cytosine base of DNA by its methylation introduced the possibility that beyond the inherent information contained within the nucleotide sequence there was an additional layer of information added to the underlying genetic code. DNA methylation has been imp