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Methylated Purines and Pyrimidines. II. Synthesis and Properties of 2,6-Diamino-5-(methylamino)-4-pyrimidinol *

✍ Scribed by Sprecher, M.; Sprinson, D. B.


Book ID
124056267
Publisher
American Chemical Society
Year
1965
Tongue
English
Weight
790 KB
Volume
4
Category
Article
ISSN
0006-2960

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Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan