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Methyl 3,3-Difluoro-2-trimethylsilyoxyacrylate: Preparation and Mukaiyama-Type Aldol Condensation as a Novel Route to β,β-Difluoro-α-keto Ester Derivatives.

✍ Scribed by Biao Jiang; Xiaobing Zhang; Guoqiang Shi

Book ID
101937114
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
33
Category
Article
ISSN
0931-7597

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Methyl 3,3-difluoro-2-trimethylsilyloxya
Methyl 3,3-difluoro-2-trimethylsilyloxyacrylate: preparation and Mukaiyama-type aldol condensation as a novel route to β,β-difluoro-α-keto ester derivatives
✍ Biao Jiang; Xiaobing Zhang; Guoqiang Shi 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 68 KB

Mukaiyama-type aldol condensation of arylaldehyde acetals occurs smoothly with methyl 3,3-difluoro-2-trimethylsilyloxyacrylate (derived from ethyl 3,3-difluoro-2-benzoylacrylate) when catalyzed by a Lewis acid, allowing preparation of 4-alkyloxy-3,3-difluoro-2-keto esters in high yields.