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Methoxyflavone Inhibitors of Cytochrome P450

✍ Scribed by Michael McKendall; Tasha Smith; Kien Anh; Jamie Ellis; Terri McGee; Maryam Foroozesh; Naijue Zhu; Cheryl L. Klein Stevens


Publisher
Springer
Year
2007
Tongue
English
Weight
277 KB
Volume
38
Category
Article
ISSN
1572-8854

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The inhibition of cytochrome P450 mediated oxidative metabolism affected by methylenedioxyphenyl synergists was studied by theoretical methods. Binding w Ε½ . conformations of safrole-based inhibitors piperonyl butoxide PBO , safrole, and x izosafrole were obtained by the recently developed low-mode