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Methoxy- and acetoxy-8-oxoberbines - synthesis, antitumor activity, and interaction with DNA

✍ Scribed by Christian Weimar; Silvia Von Angerer; Wolfgang Wiegrebe


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
750 KB
Volume
324
Category
Article
ISSN
0365-6233

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## Abstract The novel analogues **11**–**16** of bleomycin A~6~ (**3**) were obtained by selective protection of the primary‐amine function of the __Ξ²__‐aminoalaninamide moiety of **3** by means of coordination with Cu^II^ ions, condensation with an aliphatic or aromatic acid Rβ€²COOH in the presence